Correlating chemical sensitivity and basal gene expression reveals mechanism of action
نویسندگان
چکیده
منابع مشابه
Correlating chemical sensitivity and basal gene expression reveals mechanism of action
Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to ones previously established. We hypothesized that differential basal gene expression could be correlated with patterns of small-molecule sensitivity across many cell lines to illuminate the actions of compounds whose MoA are un...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2015
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.1986